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multipolar spindles
Multipolar spindles are spindle formations characteristic of cancer cells. Spindle formation is mostly conducted by the aster of the centrosome which it forms around itself. In a mitotic cell wherever two asters convene the formation of a spindle occurs.
Mitosis consists of two independent processes: the intra-chromosomal and the extra-chromosomal (formation of spindle) changes both of these being in total coordination of each other.
In cancer cells, it has been observed that the formation of the spindles comes before when compared to the chromosomes. Because the prophase stage is brief, metaphase begins earlier than in normal cells. Chromosomes unable to reach the metaphase plate are stranded behind. These chromosomes still have asters attached to them and when met with other asters, form multiple spindles.〔
==Characteristics==
Cells with multipolar spindles are characterized by more than two centrosomes, usually four, and sometimes have a second metaphase plate. The multiple centrosomes segregate to opposite ends of the cell and the spindles attach to the chromosomes haphazardly. When anaphase occurs in these cells, the chromosomes are separated abnormally and results in aneuploidy of both daughter cells. This can lead to loss of cell viability and chromosomal instability.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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